› 4bb9

X-ray diffraction
1.47Å resolution

Crystal structure of glucokinase regulatory protein complexed to fructose-1-phosphate

Released:
DOI: 10.2210/pdb4bb9/pdb
PDB entry 4bb9 coloured by chain, front view.
PDB entry 4bb9 coloured by chain, side view.
PDB entry 4bb9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of glucokinase regulatory protein.
Pautsch A, Stadler N, Löhle A, Rist W, Berg A, Glocker L, Nar H, Reinert D, Lenter M, Heckel A, Schnapp G, Kauschke SG
Biochemistry 52 3523-31 (2013)
PMID: 23621087

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171997 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucokinase regulatory protein Chain: A
Molecule details ›
Chain: A
Length: 633 amino acids
Theoretical weight: 69.78 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q14397 (Residues: 1-625; Coverage: 100%)
Gene name: GCKR
Sequence domains: C-terminal lid domain of glucokinase regulatory protein
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand F1P 1 x F1P
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 60.97Å b: 72.3Å c: 136.89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.16 0.177
Expression system: Trichoplusia ni

Quick links

Citations

7 review citations

Glucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.
Raimondo et al. (2015)
6 more

7 mentions without citation

Structural basis for regulation of human glucokinase by glucokinase regulatory protein.
Beck et al. (2013)
6 more