› 4bej

X-ray diffraction
3.48Å resolution

Nucleotide-free Dynamin 1-like protein (DNM1L, DRP1, DLP1)

Released:
DOI: 10.2210/pdb4bej/pdb
PDB entry 4bej coloured by chain, front view.
PDB entry 4bej coloured by chain, side view.
PDB entry 4bej coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.
Fröhlich C, Grabiger S, Schwefel D, Faelber K, Rosenbaum E, Mears J, Rocks O, Daumke O
EMBO J 32 1280-92 (2013)
PMID: 23584531

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126277 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dynamin-1-like protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 617 amino acids
Theoretical weight: 69.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00429 (Residues: 1-736; Coverage: 83%)
Gene names: DLP1, DNM1L, DRP1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P2
Unit cell:
a: 101.47Å b: 80.77Å c: 208.272Å
α: 90° β: 93.45° γ: 90°
R-values:
R R work R free
0.252 0.251 0.276
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

74 review citations

Mitochondrial form and function.
Friedman et al. (2014)
73 more

42 mentions without citation

Mitochondrial dynamics: The dynamin superfamily and execution by collusion.
Ramachandran R. (2018)
41 more