› 4bex

X-ray diffraction
2.8Å resolution

Structure of human Cofilin1

Released:
DOI: 10.2210/pdb4bex/pdb
PDB entry 4bex coloured by chain, front view.
PDB entry 4bex coloured by chain, side view.
PDB entry 4bex coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding.
Klejnot M, Gabrielsen M, Cameron J, Mleczak A, Talapatra SK, Kozielski F, Pannifer A, Olson MF
Acta Crystallogr D Biol Crystallogr 69 1780-8 (2013)
PMID: 23999301

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149999 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cofilin-1 Chain: 1
Molecule details ›
Chain: 1
Length: 181 amino acids
Theoretical weight: 19.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P23528 (Residues: 1-166; Coverage: 100%)
Gene names: CFL, CFL1
Sequence domains: Cofilin/tropomyosin-type actin-binding protein
Structure domains: Severin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3221
Unit cell:
a: 85.94Å b: 85.94Å c: 85.29Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.236
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

ADF/cofilin regulation from a structural viewpoint.
Narita A. (2020)
1 more

12 mentions without citation

GMF as an Actin Network Remodeling Factor.
Goode et al. (2018)
11 more