› 4bhg

X-ray diffraction
1.85Å resolution

Three dimensional structure of human gamma-butyrobetaine hydroxylase in complex with 3-(1-Ethyl-1,1-dimethylhydrazin-1-ium-2-yl)propanoate

Released:
DOI: 10.2210/pdb4bhg/pdb
PDB entry 4bhg coloured by chain, front view.
PDB entry 4bhg coloured by chain, side view.
PDB entry 4bhg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tars K, Leitans J, Kazaks A

Function and Biology Details

Reaction catalysed: 
4-trimethylammoniobutanoate + 2-oxoglutarate + O(2) = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131180 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-butyrobetaine dioxygenase Chain: A
Molecule details ›
Chain: A
Length: 387 amino acids
Theoretical weight: 44.77 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: O75936 (Residues: 1-387; Coverage: 100%)
Gene names: BBH, BBOX, BBOX1
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand OGA 1 x OGA
Ligand C2T 1 x C2T
Ligand ZN 4 x ZN
Ligand 16D 1 x 16D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: R32
Unit cell:
a: 108.18Å b: 108.18Å c: 203.18Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.153 0.151 0.19
Expression system: Saccharomyces cerevisiae

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