Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Thiol-activated cytolysin
- Ly-6 antigen/uPA receptor-like
- Snake toxin-like superfamily
- CD59 antigen, conserved site
- Thiol-activated cytolysin C-terminal
- Thiol-activated cytolysin, C-terminal domain superfamily
- Thiol-activated cytolysin, alpha-beta domain superfamily
- Thiol-activated cytolysin superfamily
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Thiol-activated cytolysin and CD59 glycoprotein (preferred)
PDBe Complex ID:
PDB-CPX-146831 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thiol-activated cytolysin
Molecule details ›
Chains: A, C
Length: 535 amino acids
Theoretical weight: 59.06 KDa
Source organism: Streptococcus intermedius
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Structure domains:
Length: 535 amino acids
Theoretical weight: 59.06 KDa
Source organism: Streptococcus intermedius
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q9LCB8 (Residues: 34-532; Coverage: 100%)
Sequence domains:
Structure domains:
CD59 glycoprotein
Molecule details ›
Chains: B, D
Length: 79 amino acids
Theoretical weight: 9.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
Sequence domains: u-PAR/Ly-6 domain
Structure domains: CD59
Length: 79 amino acids
Theoretical weight: 9.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
- Canonical: P13987 (Residues: 26-102; Coverage: 75%)
Sequence domains: u-PAR/Ly-6 domain
Structure domains: CD59
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
DIAMOND BEAMLINE I04
Spacegroup:
P1
Expression systems:
- Escherichia coli BL21(DE3)
- Escherichia coli K-12
