› 4bke

X-ray diffraction
2.35Å resolution

Recombinant human serum albumin with palmitic acid. Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin

Released:
DOI: 10.2210/pdb4bke/pdb
PDB entry 4bke coloured by chain, front view.
PDB entry 4bke coloured by chain, side view.
PDB entry 4bke coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin.
Sivertsen A, Isaksson J, Leiros HK, Svenson J, Svendsen JS, Brandsdal BO
BMC Struct Biol 14 4 (2014)
PMID: 24456893

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 609 amino acids
Theoretical weight: 69.47 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P02768 (Residues: 1-609; Coverage: 100%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

1 bound ligand:
Ligand PLM 7 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 189.366Å b: 39.003Å c: 96.296Å
α: 90° β: 105.48° γ: 90°
R-values:
R R work R free
0.202 0.198 0.254
Expression system: Saccharomyces cerevisiae

Quick links

Citations

9 review citations

Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design.
Li et al. (2017)
8 more

4 mentions without citation

Fatty acid recognition in the Frizzled receptor family.
Nile et al. (2019)
3 more