Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Sequence domains:
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Ubiquitin thioesterase OTU1 (preferred)
PDBe Complex ID:
PDB-CPX-178440 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin thioesterase OTU1
Molecule details ›
Chain: A
Length: 183 amino acids
Theoretical weight: 20.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: OTU-like cysteine protease
Structure domains: Cathepsin B; Chain A
Length: 183 amino acids
Theoretical weight: 20.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q5VVQ6 (Residues: 132-314; Coverage: 53%)
Sequence domains: OTU-like cysteine protease
Structure domains: Cathepsin B; Chain A
