› 4br1

X-ray diffraction
1.9Å resolution

Protease-induced heterodimer of human triosephosphate isomerase.

Released:
DOI: 10.2210/pdb4br1/pdb
PDB entry 4br1 coloured by chain, front view.
PDB entry 4br1 coloured by chain, side view.
PDB entry 4br1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: DeLaMora-DeLaMora I, Torres-Larios A, Hernandez-Alcantara G, Mendoza-Hernandez G, Enriquez-Flores S, Mendez ST, Castillo-Villanueva A, Garcia-Torres I, Torres-Arroyo A, Gomez-Manzo S, Marcial-Quino J, Oria-Hernandez J, Lopez-Velazquez G, Reyes-Vivas H

Function and Biology Details

Reactions catalysed: 
Glycerone phosphate = methylglyoxal + phosphate
D-glyceraldehyde 3-phosphate = glycerone phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157974 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Triosephosphate isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 246 amino acids
Theoretical weight: 26.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P60174 (Residues: 4-249; Coverage: 99%)
Gene names: TPI, TPI1
Sequence domains: Triosephosphate isomerase
Structure domains: Aldolase class I

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 68.301Å b: 77.317Å c: 87.311Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.217
Expression system: Escherichia coli BL21(DE3)

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