› 4bsj

X-ray diffraction
2.5Å resolution

Crystal structure of VEGFR-3 extracellular domains D4-5

Released:
DOI: 10.2210/pdb4bsj/pdb
PDB entry 4bsj coloured by chain, front view.
PDB entry 4bsj coloured by chain, side view.
PDB entry 4bsj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.
Leppänen VM, Tvorogov D, Kisko K, Prota AE, Jeltsch M, Anisimov A, Markovic-Mueller S, Stuttfeld E, Goldie KN, Ballmer-Hofer K, Alitalo K
Proc Natl Acad Sci U S A 110 12960-5 (2013)
PMID: 23878260

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153054 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vascular endothelial growth factor receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 232 amino acids
Theoretical weight: 26.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P35916 (Residues: 330-553; Coverage: 17%)
Gene names: FLT4, VEGFR3
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3121
Unit cell:
a: 133.34Å b: 133.34Å c: 48.93Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.21 0.253
Expression system: Spodoptera frugiperda

Quick links

Citations

21 review citations

Hypoxia and lymphangiogenesis in tumor microenvironment and metastasis.
Ji RC. (2014)
20 more

10 mentions without citation

Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy.
Shaik et al. (2020)
9 more