› 4bvd

X-ray diffraction
1.68Å resolution

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Released:
DOI: 10.2210/pdb4bvd/pdb
PDB entry 4bvd coloured by chain, front view.
PDB entry 4bvd coloured by chain, side view.
PDB entry 4bvd coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sandmark J, Althage M, Andersson GMK, Antonsson T, Blaho S, Bodin C, Bostrom J, Chen Y, Dahlen A, Eriksson PO, Evertsson E, Fex T, Fjellstrom O, Gustafsson D, Hallberg C, Hicks R, Jarkvist E, Johansson C, Kalies I, Kang D, Svalstedt Karlsson B, Kartberg F, Legnehed A, Lindqvist AM, Martinsson SA, Moberg A, Petersson AU, Ridderstrom M, Thelin A, Tigerstrom A, Vinblad J, Xu B, Knecht W

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein(a) Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 9.16 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08519 (Residues: 1615-1693; Coverage: 4%)
Gene name: LPA
Sequence domains: Kringle domain
Structure domains: Plasminogen Kringle 4

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand BU6 1 x BU6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+
Unit cell:
a: 24.24Å b: 45.27Å c: 58.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.214
Expression system: Komagataella pastoris

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