› 4byh

X-ray diffraction
2.3Å resolution

Crystal structure of sialylated IgG Fc

Released:
DOI: 10.2210/pdb4byh/pdb
PDB entry 4byh coloured by chain, front view.
PDB entry 4byh coloured by chain, side view.
PDB entry 4byh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of sialylated IgG Fc: implications for the mechanism of intravenous immunoglobulin therapy.
Crispin M, Yu X, Bowden TA
Proc Natl Acad Sci U S A 110 E3544-6 (2013)
PMID: 23929778

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 233 amino acids
Theoretical weight: 26.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 106-329; Coverage: 56%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, SIA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUC
Carbohydrate polymer
1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P6122
Unit cell:
a: 153Å b: 153Å c: 111.85Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.222 0.262
Expression system: Homo sapiens

Quick links

Citations

31 review citations

Biological roles of glycans.
Varki A. (2017)
30 more

30 mentions without citation

Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life.
Saunders KO. (2019)
29 more