› 4c0g

X-ray diffraction
2.4Å resolution

Structure of the NOT-box domain of human CNOT3

Released:
DOI: 10.2210/pdb4c0g/pdb
PDB entry 4c0g coloured by chain, front view.
PDB entry 4c0g coloured by chain, side view.
PDB entry 4c0g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and assembly of the NOT module of the human CCR4-NOT complex.
Boland A, Chen Y, Raisch T, Jonas S, Kuzuoğlu-Öztürk D, Wohlbold L, Weichenrieder O, Izaurralde E
Nat Struct Mol Biol 20 1289-97 (2013)
PMID: 24121232

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130879 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CCR4-NOT transcription complex subunit 3 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 102 amino acids
Theoretical weight: 12.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75175 (Residues: 656-753; Coverage: 13%)
Gene names: CNOT3, KIAA0691, LENG2, NOT3
Sequence domains: NOT2/NOT3/NOT5 C-terminal
Structure domains: CCR4-NOT complex subunit 2/3/5, C-terminal domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 18 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 52.3Å b: 97.57Å c: 141.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.221 0.257
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

14 review citations

Deadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects.
Temme et al. (2014)
13 more

1 mention without citation

Insights into the structure and architecture of the CCR4-NOT complex.
Xu et al. (2014)