› 4c54

X-ray diffraction
1.9Å resolution

Crystal structure of recombinant human IgG4 Fc

Released:
DOI: 10.2210/pdb4c54/pdb
PDB entry 4c54 coloured by chain, front view.
PDB entry 4c54 coloured by chain, side view.
PDB entry 4c54 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural determinants of unique properties of human IgG4-Fc.
Davies AM, Rispens T, Ooijevaar-de Heer P, Gould HJ, Jefferis R, Aalberse RC, Sutton BJ
J Mol Biol 426 630-44 (2014)
PMID: 24211234

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134888 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin heavy constant gamma 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 214 amino acids
Theoretical weight: 24.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01861 (Residues: 114-325; Coverage: 54%)
Gene name: IGHG4
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
2 bound ligands:
Ligand MES 2 x MES
Ligand EDO 9 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 74.837Å b: 78.973Å c: 97.881Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.209
Expression system: Homo sapiens

Quick links

Citations

19 review citations

Type I and type II Fc receptors regulate innate and adaptive immunity.
Pincetic et al. (2014)
18 more

23 mentions without citation

Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy.
Mimura et al. (2018)
22 more