› 4c9h

X-ray diffraction
3.2Å resolution

Structure of yeast mitochondrial ADP/ATP carrier isoform 2 inhibited by carboxyatractyloside (P212121 crystal form)

Released:
DOI: 10.2210/pdb4c9h/pdb
PDB entry 4c9h coloured by chain, front view.
PDB entry 4c9h coloured by chain, side view.
PDB entry 4c9h coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism.
Ruprecht JJ, Hellawell AM, Harding M, Crichton PG, McCoy AJ, Kunji ER
Proc Natl Acad Sci U S A 111 E426-34 (2014)
PMID: 24474793

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148334 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP,ATP carrier protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 318 amino acids
Theoretical weight: 34.47 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P18239 (Residues: 1-318; Coverage: 100%)
Gene names: AAC2, PET9, YBL030C, YBL0421
Sequence domains: Mitochondrial carrier protein
Structure domains: Mitochondrial carrier domain

Ligands and Environments

3 bound ligands:
Ligand CXT 2 x CXT
Ligand CDL 6 x CDL
Ligand CM5 1 x CM5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 67.354Å b: 98.203Å c: 105.061Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.249 0.28
Expression system: Saccharomyces cerevisiae

Quick links

Citations

29 review citations

Metabolism and function of mitochondrial cardiolipin.
Ren et al. (2014)
28 more

14 mentions without citation

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism.
Ruprecht et al. (2020)
13 more