› 4c9q

X-ray diffraction
3.2Å resolution

Structure of yeast mitochondrial ADP/ATP carrier isoform 3 inhibited by carboxyatractyloside (P21 crystal form)

Released:
DOI: 10.2210/pdb4c9q/pdb
PDB entry 4c9q coloured by chain, front view.
PDB entry 4c9q coloured by chain, side view.
PDB entry 4c9q coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism.
Ruprecht JJ, Hellawell AM, Harding M, Crichton PG, McCoy AJ, Kunji ER
Proc Natl Acad Sci U S A 111 E426-34 (2014)
PMID: 24474793

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148333 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP,ATP carrier protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 322 amino acids
Theoretical weight: 35.26 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P18238 (Residues: 3-307; Coverage: 99%)
Gene names: AAC3, YBR0753, YBR085W
Sequence domains: Mitochondrial carrier protein
Structure domains: Mitochondrial carrier domain

Ligands and Environments

2 bound ligands:
Ligand CXT 2 x CXT
Ligand CDL 6 x CDL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 56.695Å b: 107.876Å c: 57.002Å
α: 90° β: 93.62° γ: 90°
R-values:
R R work R free
0.26 0.258 0.295
Expression system: Saccharomyces cerevisiae

Quick links

Citations

28 review citations

Metabolism and function of mitochondrial cardiolipin.
Ren et al. (2014)
27 more

15 mentions without citation

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism.
Ruprecht et al. (2020)
14 more