› 4cby

X-ray diffraction
2.72Å resolution

Function and Biology Details

Reaction catalysed: 
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157479 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone deacetylase 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 395 amino acids
Theoretical weight: 42.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P56524 (Residues: 648-1033; Coverage: 36%)
Gene names: HDAC4, KIAA0288
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain

Ligands and Environments

3 bound ligands:
Ligand KEE 4 x KEE
Ligand ZN 8 x ZN
Ligand NA 8 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 54.151Å b: 161.816Å c: 83.732Å
α: 90° β: 97.03° γ: 90°
R-values:
R R work R free
0.211 0.209 0.246
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

18 review citations

Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach.
Nah et al. (2015)
17 more

11 mentions without citation

Guidelines for the successful generation of protein-ligand complex crystals.
Müller I. (2017)
10 more