› 4cc2

X-ray diffraction
1.55Å resolution

Complex of human Tuba C-terminal SH3 domain with human N-WASP proline- rich peptide - P212121

Released:
DOI: 10.2210/pdb4cc2/pdb
PDB entry 4cc2 coloured by chain, front view.
PDB entry 4cc2 coloured by chain, side view.
PDB entry 4cc2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural details of human tuba recruitment by InlC of Listeria monocytogenes elucidate bacterial cell-cell spreading.
Polle L, Rigano LA, Julian R, Ireton K, Schubert WD
Structure 22 304-14 (2014)
PMID: 24332715

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126259 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dynamin-binding protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 67 amino acids
Theoretical weight: 7.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q6XZF7 (Residues: 1513-1577; Coverage: 4%)
Gene names: ARHGEF36, DNMBP, KIAA1010, TUBA
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains
Actin nucleation-promoting factor WASL Chains: B, D
Molecule details ›
Chains: B, D
Length: 12 amino acids
Theoretical weight: 1.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O00401 (Residues: 346-357; Coverage: 2%)
Gene name: WASL

Ligands and Environments

2 bound ligands:
Ligand GOL 4 x GOL
Ligand CL 8 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P212121
Unit cell:
a: 48.75Å b: 70.31Å c: 38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.218
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

5 review citations

Listeriosis in animals, its public health significance (food-borne zoonosis) and advances in diagnosis and control: a comprehensive review.
Dhama et al. (2015)
4 more

2 mentions without citation

Analysis of gene variants in the GASH/Sal model of epilepsy.
Díaz-Casado et al. (2020)
1 more