› 4cca

X-ray diffraction
2.6Å resolution

Structure of human Munc18-2

Released:
DOI: 10.2210/pdb4cca/pdb
PDB entry 4cca coloured by chain, front view.
PDB entry 4cca coloured by chain, side view.
PDB entry 4cca coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Syntaxin binding mechanism and disease-causing mutations in Munc18-2.
Hackmann Y, Graham SC, Ehl S, Höning S, Lehmberg K, Aricò M, Owen DJ, Griffiths GM
Proc Natl Acad Sci U S A 110 E4482-91 (2013)
PMID: 24194549

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172424 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Syntaxin-binding protein 2 Chain: A
Molecule details ›
Chain: A
Length: 598 amino acids
Theoretical weight: 67.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15833 (Residues: 1-593; Coverage: 100%)
Gene names: STXBP2, UNC18B
Sequence domains: Sec1 family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P41212
Unit cell:
a: 67.55Å b: 67.55Å c: 284.651Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.242 0.275
Expression system: Spodoptera frugiperda

Quick links

Citations

21 review citations

Primary Immunodeficiencies Associated with EBV Disease.
Cohen JI. (2015)
20 more

11 mentions without citation

MYO5B, STX3, and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update.
Dhekne et al. (2018)
10 more