Function and Biology Details
Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173733 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
E3 ubiquitin-protein ligase ZNRF3
Molecule details ›
Chains: A, B, C, D
Length: 164 amino acids
Theoretical weight: 17.99 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
Sequence domains: ZNRF-3 Ectodomain
Structure domains: Glucose Oxidase; domain 1
Length: 164 amino acids
Theoretical weight: 17.99 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
- Canonical:
Q5SSZ7 (Residues: 53-205; Coverage: 18%)
Sequence domains: ZNRF-3 Ectodomain
Structure domains: Glucose Oxidase; domain 1
R-spondin-1
Molecule details ›
Chains: E, F, G, H
Length: 126 amino acids
Theoretical weight: 13.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Furin-like repeat, cysteine-rich
Structure domains: Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Length: 126 amino acids
Theoretical weight: 13.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q2MKA7 (Residues: 31-145; Coverage: 47%)
Sequence domains: Furin-like repeat, cysteine-rich
Structure domains: Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SLS BEAMLINE X06SA
Spacegroup:
P1
Expression system: Homo sapiens
