› 4cg4

X-ray diffraction
2.4Å resolution

Crystal structure of the CHS-B30.2 domains of TRIM20

Released:
DOI: 10.2210/pdb4cg4/pdb
PDB entry 4cg4 coloured by chain, front view.
PDB entry 4cg4 coloured by chain, side view.
PDB entry 4cg4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomers.
Weinert C, Morger D, Djekic A, Grütter MG, Mittl PR
Sci Rep 5 10819 (2015)
PMID: 26043233

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127533 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyrin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 377 amino acids
Theoretical weight: 42.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15553 (Residues: 414-781; Coverage: 47%)
Gene names: MEF, MEFV, TRIM20
Sequence domains:
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand SO4 8 x SO4
Ligand EDO 2 x EDO
Ligand DHL 5 x DHL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 69.82Å b: 388.21Å c: 70.88Å
α: 90° β: 116.52° γ: 90°
R-values:
R R work R free
0.214 0.212 0.261
Expression system: Spodoptera frugiperda

Quick links

Citations

15 review citations

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis.
Hatakeyama S. (2017)
14 more

5 mentions without citation

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.
Lim et al. (2019)
4 more