› 4cg8

X-ray diffraction
1.75Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + choline = ADP + phosphocholine
ATP + ethanolamine = ADP + O-phosphoethanolamine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153023 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Choline kinase alpha Chain: A
Molecule details ›
Chain: A
Length: 383 amino acids
Theoretical weight: 44.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35790 (Residues: 75-457; Coverage: 84%)
Gene names: CHK, CHKA, CKI
Sequence domains: Choline/ethanolamine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand G8S 1 x G8S
Ligand G8V 1 x G8V
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P43212
Unit cell:
a: 61.554Å b: 61.554Å c: 221.113Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.203 0.224
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Choline metabolism-based molecular diagnosis of cancer: an update.
Glunde et al. (2015)
1 more

4 mentions without citation

Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death.
Serrán-Aguilera et al. (2016)
3 more