Function and Biology Details
Reaction catalysed:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA topoisomerase, type IA, central
- TOPRIM domain
- RecQ mediated genome instability protein, N-terminal OB-fold domain superfamily
- RecQ mediated genome instability protein 1, OB-fold domain
- RecQ mediated genome instability protein 1-like, N-terminal domain
- RecQ-mediated genome instability protein 1, N-terminal helical domain superfamily
- DNA topoisomerase, type IA, zn finger
- DNA topoisomerase, type IA, active site
8 more domains
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171706 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA topoisomerase 3-alpha
Molecule details ›
Chain: A
Length: 754 amino acids
Theoretical weight: 86.58 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Structure domains:
Length: 754 amino acids
Theoretical weight: 86.58 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q13472 (Residues: 2-753; Coverage: 75%)
Sequence domains:
Structure domains:
RecQ-mediated genome instability protein 1
Molecule details ›
Chain: B
Length: 219 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Structure domains:
Length: 219 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: Q9H9A7 (Residues: 1-219; Coverage: 35%)
Sequence domains:
Structure domains:
