› 4ci9

X-ray diffraction
1.58Å resolution

Crystal structure of cathepsin A, apo-structure

Released:
DOI: 10.2210/pdb4ci9/pdb
PDB entry 4ci9 coloured by chain, front view.
PDB entry 4ci9 coloured by chain, side view.
PDB entry 4ci9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases.
Schreuder HA, Liesum A, Kroll K, Böhnisch B, Buning C, Ruf S, Sadowski T
Biochem Biophys Res Commun 445 451-6 (2014)
PMID: 24530914

Function and Biology Details

Reaction catalysed: 
Release of a C-terminal amino acid with broad specificity.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145363 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Lysosomal protective protein Chain: A
Molecule details ›
Chain: A
Length: 455 amino acids
Theoretical weight: 51.83 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P10619 (Residues: 29-480; Coverage: 100%)
Gene names: CTSA, PPGB
Sequence domains: Serine carboxypeptidase
Structure domains: alpha/beta hydrolase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand DMS 1 x DMS
Ligand ACT 2 x ACT
Ligand GOL 2 x GOL
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 90.31Å b: 102.03Å c: 48.55Å
α: 90° β: 101.27° γ: 90°
R-values:
R R work R free
0.166 0.165 0.19
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Small molecule and peptide therapies for chronic heart failure: a patent review (2011 - 2014).
Raymer et al. (2015)
3 other articles

1 mention without citation

Discovery of Leishmania Druggable Serine Proteases by Activity-Based Protein Profiling.
Porta et al. (2022)