› 4cp3

X-ray diffraction
2.3Å resolution

The structure of BCL6 BTB (POZ) domain in complex with the ansamycin antibiotic rifabutin.

Released:
DOI: 10.2210/pdb4cp3/pdb
PDB entry 4cp3 coloured by chain, front view.
PDB entry 4cp3 coloured by chain, side view.
PDB entry 4cp3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.
Evans SE, Goult BT, Fairall L, Jamieson AG, Ko Ferrigno P, Ford R, Schwabe JW, Wagner SD
PLoS One 9 e90889 (2014)
PMID: 24595451

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154263 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
B-cell lymphoma 6 protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 14.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41182 (Residues: 9-128; Coverage: 17%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

1 bound ligand:
Ligand RBT 1 x RBT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 35.172Å b: 54.828Å c: 58.159Å
α: 90° β: 95.21° γ: 90°
R-values:
R R work R free
0.202 0.199 0.269
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

The Expanding Role of the BCL6 Oncoprotein as a Cancer Therapeutic Target.
Cardenas et al. (2017)
1 more

3 mentions without citation

Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
Zhang et al. (2018)
2 more