› 4ct5

X-ray diffraction
3Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150664 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable ATP-dependent RNA helicase DDX6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 378 amino acids
Theoretical weight: 43.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26196 (Residues: 95-469; Coverage: 78%)
Gene names: DDX6, HLR2, RCK
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 113.116Å b: 113.144Å c: 77.183Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.231 0.262
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

48 review citations

Towards a molecular understanding of microRNA-mediated gene silencing.
Jonas et al. (2015)
47 more

7 mentions without citation

Host DDX Helicases as Possible SARS-CoV-2 Proviral Factors: A Structural Overview of Their Hijacking Through Multiple Viral Proteins.
Squeglia et al. (2020)
6 more