› 4ct6

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107791 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
CCR4-NOT transcription complex subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 243 amino acids
Theoretical weight: 27.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: A5YKK6 (Residues: 1352-1594; Coverage: 10%)
Gene names: AD-005, CDC39, CNOT1, KIAA1007, NOT1
Sequence domains: CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
CCR4-NOT transcription complex subunit 9 Chain: B
Molecule details ›
Chain: B
Length: 270 amino acids
Theoretical weight: 30.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q92600 (Residues: 18-285; Coverage: 90%)
Gene names: CNOT9, RCD1, RQCD1
Sequence domains: Cell differentiation family, Rcd1-like
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 153.67Å b: 66.142Å c: 72.436Å
α: 90° β: 100.35° γ: 90°
R-values:
R R work R free
0.196 0.194 0.236
Expression system: Escherichia coli BL21

Quick links

Citations

47 review citations

Towards a molecular understanding of microRNA-mediated gene silencing.
Jonas et al. (2015)
46 more

1 mention without citation

Structure and function of molecular machines involved in deadenylation-dependent 5'-3' mRNA degradation.
Zhao et al. (2023)