› 4cy5

X-ray diffraction
2.3Å resolution

Function and Biology Details

Reaction catalysed: 
Diphosphate + H(2)O = 2 phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-107436 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Protein will die slowly Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 34.67 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9V3J8 (Residues: 50-361; Coverage: 86%)
Gene names: CG17437, l(1)3Ad, l(1)zw8, wds
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
KAT8 regulatory NSL complex subunit 2 Chain: C
Molecule details ›
Chain: C
Length: 13 amino acids
Theoretical weight: 1.56 KDa
Source organism: Drosophila melanogaster
Expression system: Not provided
UniProt:
  • Canonical: Q9VAF4 (Residues: 155-166; Coverage: 3%)
Gene names: CG18041, Dgt1, Dmel\CG18041, Dmel_CG18041, NSL2, dgt1
PEHE domain-containing protein Chain: D
Molecule details ›
Chain: D
Length: 16 amino acids
Theoretical weight: 1.77 KDa
Source organism: Drosophila melanogaster
Expression system: Not provided
UniProt:
  • Canonical: A4V2Z1 (Residues: 714-729; Coverage: 1%)
Gene names: CG4699, Dmel\CG4699, Dmel_CG4699, E(nos), NSL1, Nsl1, l(3)06536, l(3)S009413, nsl1, wah

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21212
Unit cell:
a: 81.48Å b: 86.21Å c: 47.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.245
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

9 review citations

Moonlighting with WDR5: A Cellular Multitasker.
Guarnaccia et al. (2018)
8 more

1 mention without citation

Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex.
Dias et al. (2014)