› 4cyg

X-ray diffraction
2.3Å resolution

The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation

Released:
DOI: 10.2210/pdb4cyg/pdb
PDB entry 4cyg coloured by chain, front view.
PDB entry 4cyg coloured by chain, side view.
PDB entry 4cyg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.
Boersma YL, Newman J, Adams TE, Cowieson N, Krippner G, Bozaoglu K, Peat TS
Acta Crystallogr D Biol Crystallogr 70 3320-9 (2014)
PMID: 25478849

Function and Biology Details

Reaction catalysed: 
(R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131943 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Pantetheinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 506 amino acids
Theoretical weight: 56.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O95497 (Residues: 22-513; Coverage: 100%)
Gene name: VNN1
Sequence domains:
Structure domains: Carbon-nitrogen hydrolase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand RRV 2 x RRV
Ligand NAG 6 x NAG
Ligand PEG 2 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 120.093Å b: 120.093Å c: 221.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.214
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Regulation of coenzyme A levels by degradation: the 'Ins and Outs'.
Naquet et al. (2020)
2 more

3 mentions without citation

Biological function derived from predicted structures in CASP11.
Huwe et al. (2016)
2 more