› 4d1e

X-ray diffraction
3.5Å resolution

THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2

Released:
DOI: 10.2210/pdb4d1e/pdb
PDB entry 4d1e coloured by chain, front view.
PDB entry 4d1e coloured by chain, side view.
PDB entry 4d1e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure and regulation of human muscle α-actinin.
Ribeiro Ede A, Pinotsis N, Ghisleni A, Salmazo A, Konarev PV, Kostan J, Sjöblom B, Schreiner C, Polyansky AA, Gkougkoulia EA, Holt MR, Aachmann FL, Zagrović B, Bordignon E, Pirker KF, Svergun DI, Gautel M, Djinović-Carugo K
Cell 159 1447-60 (2014)
PMID: 25433700

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-actinin-2 Chain: A
Molecule details ›
Chain: A
Length: 876 amino acids
Theoretical weight: 101.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35609 (Residues: 19-894; Coverage: 98%)
Gene name: ACTN2
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MLZ 13 x MLZ

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Unit cell:
a: 73.334Å b: 102.613Å c: 182.977Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.258
Expression system: Escherichia coli BL21(DE3)

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Citations

28 review citations

Overview of the Muscle Cytoskeleton.
Henderson et al. (2017)
27 more

23 mentions without citation

Genetic Insights into Primary Restrictive Cardiomyopathy.
Brodehl et al. (2022)
22 more