› 4d2n

X-ray diffraction
2.7Å resolution

Crystal structure of deglycosylated serum-derived human IgG4 Fc

Released:
DOI: 10.2210/pdb4d2n/pdb
PDB entry 4d2n coloured by chain, front view.
PDB entry 4d2n coloured by chain, side view.
PDB entry 4d2n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of deglycosylated human IgG4-Fc.
Davies AM, Jefferis R, Sutton BJ
Mol Immunol 62 46-53 (2014)
PMID: 24956411

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134888 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin heavy constant gamma 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 226 amino acids
Theoretical weight: 25.45 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01861 (Residues: 102-325; Coverage: 57%)
Gene name: IGHG4
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P622
Unit cell:
a: 196.945Å b: 196.945Å c: 96.956Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.204 0.254

Quick links

Citations

12 review citations

Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life.
Saunders KO. (2019)
11 more

6 mentions without citation

Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy.
Mimura et al. (2018)
5 more