› 4d3c

X-ray diffraction
2.62Å resolution

Crystal structure of the NK1 domain of HGF in complex with anti-HGF monoclonal antibody SFN68.

Released:
DOI: 10.2210/pdb4d3c/pdb
PDB entry 4d3c coloured by chain, front view.
PDB entry 4d3c coloured by chain, side view.
PDB entry 4d3c coloured by chain, top view.
Source organisms:
Entry authors: Kang YJ, Kim KL, Cho HS, Chung JH

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-208533 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Hepatocyte growth factor alpha chain Chain: A
Molecule details ›
Chain: A
Length: 193 amino acids
Theoretical weight: 22.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14210 (Residues: 32-210; Coverage: 26%)
Gene names: HGF, HPTA
Sequence domains:
Structure domains: Plasminogen Kringle 4
SFN68 FAB Chain: H
Molecule details ›
Chain: H
Length: 218 amino acids
Theoretical weight: 23.23 KDa
Source organism: Oryctolagus cuniculus
Structure domains: Immunoglobulins
Ig-like domain-containing protein; Immunoglobulin kappa constant Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 22.97 KDa
Source organisms: UniProt:
  • Canonical: U3KM01 (Residues: 23-133; Coverage: 80%)
  • Canonical: P01834 (Residues: 2-107; Coverage: 99%)
Gene name: IGKC
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS
Spacegroup: C2221
Unit cell:
a: 86.703Å b: 297.692Å c: 70.713Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.269 0.268 0.298
Expression system: Escherichia coli

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