› 4d7g

X-ray diffraction
2.33Å resolution

Human FXIa in complex with small molecule inhibitors.

Released:
DOI: 10.2210/pdb4d7g/pdb
PDB entry 4d7g coloured by chain, front view.
PDB entry 4d7g coloured by chain, side view.
PDB entry 4d7g coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sandmark J, Oster L, Jacso T, Ullah V, Redzick A, Borjesson U, Olsson T, Norberg M, Akerud T

Function and Biology Details

Reaction catalysed: 
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137278 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Coagulation factor XIa light chain Chain: A
Molecule details ›
Chain: A
Length: 238 amino acids
Theoretical weight: 26.75 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P03951 (Residues: 388-625; Coverage: 39%)
Gene name: F11
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

4 bound ligands:
Ligand GOL 6 x GOL
Ligand E6U 1 x E6U
Ligand SO4 5 x SO4
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: I23
Unit cell:
a: 120.929Å b: 120.929Å c: 120.929Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.224 0.249
Expression system: Komagataella pastoris

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