› 4ddj

X-ray diffraction
1.9Å resolution

Crystal structure of saposin A in complex with lauryldimethylamine-N-oxide (LDAO)

Released:
DOI: 10.2210/pdb4ddj/pdb
PDB entry 4ddj coloured by chain, front view.
PDB entry 4ddj coloured by chain, side view.
PDB entry 4ddj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of saposin A lipoprotein discs.
Popovic K, Holyoake J, Pomès R, Privé GG
Proc Natl Acad Sci U S A 109 2908-12 (2012)
PMID: 22308394

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139657 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Saposin-A Chain: A
Molecule details ›
Chain: A
Length: 83 amino acids
Theoretical weight: 9.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07602 (Residues: 60-140; Coverage: 16%)
Gene names: GLBA, PSAP, SAP1
Sequence domains:
Structure domains: Saposin-like

Ligands and Environments

1 bound ligand:
Ligand LDA 20 x LDA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID, RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P6122
Unit cell:
a: 39.794Å b: 39.794Å c: 247.284Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.23 0.28
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Perspective on the Martini model.
Marrink et al. (2013)
7 more

17 mentions without citation

Structure and Dynamics of GPCRs in Lipid Membranes: Physical Principles and Experimental Approaches.
Jones et al. (2020)
16 more