› 4deh

X-ray diffraction
2Å resolution

Crystal structure of c-Met in complex with triazolopyridinone inhibitor 3

Released:
DOI: 10.2210/pdb4deh/pdb
PDB entry 4deh coloured by chain, front view.
PDB entry 4deh coloured by chain, side view.
PDB entry 4deh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bode CM, Boezio AA, Albrecht BK, Bellon SF, Berry L, Broome MA, Choquette D, Dussault I, Lewis RT, Lin MH, Rex K, Whittington DA, Yang Y, Harmange JC
Bioorg Med Chem Lett 22 4089-93 (2012)
PMID: 22595176

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140186 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 35.22 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P08581 (Residues: 1048-1351; Coverage: 22%)
Gene name: MET
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 0JK 1 x 0JK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 41.964Å b: 42.747Å c: 158.44Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.259
Expression system: Trichoplusia ni

Quick links

Citations

1 review citation

The Exploration of Chirality for Improved Druggability within the Human Kinome.
Saha et al. (2020)

2 mentions without citation

Data driven polypharmacological drug design for lung cancer: analyses for targeting ALK, MET, and EGFR.
Narayanan et al. (2017)
1 more