Function and Biology Details
Reaction catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-134411 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interleukin-1 beta
Molecule details ›
Chains: A, D
Length: 158 amino acids
Theoretical weight: 17.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Length: 158 amino acids
Theoretical weight: 17.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P01584 (Residues: 117-269; Coverage: 57%)
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Interleukin-1 receptor type 1, soluble form
Molecule details ›
Chains: B, E
Length: 321 amino acids
Theoretical weight: 36.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Structure domains: Immunoglobulins
Length: 321 amino acids
Theoretical weight: 36.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P14778 (Residues: 18-336; Coverage: 58%)
Sequence domains:
Structure domains: Immunoglobulins
Interleukin-1 receptor accessory protein
Molecule details ›
Chains: C, F
Length: 349 amino acids
Theoretical weight: 40.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins
Length: 349 amino acids
Theoretical weight: 40.11 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9NPH3 (Residues: 21-367; Coverage: 63%)
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins
