› 4dfi

X-ray diffraction
1.8Å resolution

Crystal structure of cell adhesion molecule nectin-2/CD112 mutant FAMP

Released:
DOI: 10.2210/pdb4dfi/pdb
PDB entry 4dfi coloured by chain, front view.
PDB entry 4dfi coloured by chain, side view.
PDB entry 4dfi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226.
Liu J, Qian X, Chen Z, Xu X, Gao F, Zhang S, Zhang R, Qi J, Gao GF, Yan J
J Immunol 188 5511-20 (2012)
PMID: 22547693

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187721 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nectin-2 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 13.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92692 (Residues: 32-158; Coverage: 25%)
Gene names: HVEB, NECTIN2, PRR2, PVRL2
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 43.272Å b: 45.78Å c: 52.641Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.197 0.237
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Balancing natural killer cell activation through paired receptors.
Martinet et al. (2015)
9 more