› 4dgg

X-ray diffraction
2.65Å resolution

c-SRC kinase domain in complex with RM-1-176

Released:
DOI: 10.2210/pdb4dgg/pdb
PDB entry 4dgg coloured by chain, front view.
PDB entry 4dgg coloured by chain, side view.
PDB entry 4dgg coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Active site profiling reveals coupling between domains in SRC-family kinases.
Krishnamurty R, Brigham JL, Leonard SE, Ranjitkar P, Larson ET, Dale EJ, Merritt EA, Maly DJ
Nat Chem Biol 9 43-50 (2013)
PMID: 23143416

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.73 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00523 (Residues: 251-533; Coverage: 53%)
Gene name: SRC
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand I76 2 x I76
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P1
Unit cell:
a: 42.17Å b: 63.48Å c: 74Å
α: 78.73° β: 88.48° γ: 89.93°
R-values:
R R work R free
0.21 0.208 0.252
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells.
Poh et al. (2015)
7 more

4 mentions without citation

Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.
Kwarcinski et al. (2016)
3 more