› 4djn

X-ray diffraction
2.2Å resolution

Crystal structure of a ribonucleotide reductase M2 B (RNRR2) from Homo sapiens at 2.20 A resolution

Released:
DOI: 10.2210/pdb4djn/pdb
PDB entry 4djn coloured by chain, front view.
PDB entry 4djn coloured by chain, side view.
PDB entry 4djn coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)

Function and Biology Details

Reaction catalysed: 
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181651 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonucleoside-diphosphate reductase subunit M2 B Chains: A, B
Molecule details ›
Chains: A, B
Length: 311 amino acids
Theoretical weight: 36.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7LG56 (Residues: 13-322; Coverage: 88%)
Gene names: P53R2, RRM2B
Sequence domains: Ribonucleotide reductase, small chain
Structure domains: Ribonucleotide Reductase, subunit A

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand EDO 2 x EDO
1 modified residue:
Ligand MSE 16 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 69.053Å b: 98.762Å c: 133.668Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.193 0.219
Expression system: Escherichia coli

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