› 4dmy

X-ray diffraction
1.63Å resolution

Function and Biology Details

Reaction catalysed: 
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154996 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin K Chains: A, B
Molecule details ›
Chains: A, B
Length: 215 amino acids
Theoretical weight: 23.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43235 (Residues: 115-329; Coverage: 69%)
Gene names: CTSK, CTSO, CTSO2
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

3 bound ligands:
Ligand 0LC 2 x 0LC
Ligand SO4 4 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 31.927Å b: 69.554Å c: 90.645Å
α: 90° β: 99.83° γ: 90°
R-values:
R R work R free
0.13 0.128 0.19
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Advances in the discovery of cathepsin K inhibitors on bone resorption.
Lu et al. (2018)
12 other articles

1 mention without citation

Prognostic and therapeutic relevance of cathepsin B in pediatric acute myeloid leukemia.
Pandey et al. (2019)