› 4dom

X-ray diffraction
1.8Å resolution

Crystal Structure of the TIR-domain of Human Myeloid Differentiation Primary Response protein (MyD88)

Released:
DOI: 10.2210/pdb4dom/pdb
PDB entry 4dom coloured by chain, front view.
PDB entry 4dom coloured by chain, side view.
PDB entry 4dom coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.
Snyder GA, Cirl C, Jiang J, Chen K, Waldhuber A, Smith P, Römmler F, Snyder N, Fresquez T, Dürr S, Tjandra N, Miethke T, Xiao TS
Proc Natl Acad Sci U S A 110 6985-90 (2013)
PMID: 23569230

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189282 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myeloid differentiation primary response protein MyD88 Chain: A
Molecule details ›
Chain: A
Length: 141 amino acids
Theoretical weight: 16.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99836 (Residues: 157-296; Coverage: 47%)
Gene name: MYD88
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands
2 modified residues:
Ligand CSO 2 x CSO
Ligand MLY 5 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 33.415Å b: 57.991Å c: 62.495Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.216
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains.
Ve et al. (2015)
8 more

11 mentions without citation

International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.
Bryant et al. (2015)
10 more