› 4dum

X-ray diffraction
2.95Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139166 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 4E Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 28.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06730 (Residues: 1-217; Coverage: 100%)
Gene names: EIF4E, EIF4EL1, EIF4F
Sequence domains: Eukaryotic initiation factor 4E
Structure domains: RNA Cap, Translation Initiation Factor Eif4e

Ligands and Environments

2 bound ligands:
Ligand HLI 1 x HLI
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 38.225Å b: 58.766Å c: 125.442Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.202 0.271
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Targeting the translation machinery in cancer.
Bhat et al. (2015)
13 more

1 mention without citation

Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.
Wan et al. (2020)