› 4dur

X-ray diffraction
2.45Å resolution

The X-ray Crystal Structure of Full-Length type II Human Plasminogen

Released:
DOI: 10.2210/pdb4dur/pdb
PDB entry 4dur coloured by chain, front view.
PDB entry 4dur coloured by chain, side view.
PDB entry 4dur coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The X-ray crystal structure of full-length human plasminogen.
Law RH, Caradoc-Davies T, Cowieson N, Horvath AJ, Quek AJ, Encarnacao JA, Steer D, Cowan A, Zhang Q, Lu BG, Pike RN, Smith AI, Coughlin PB, Whisstock JC
Cell Rep 1 185-90 (2012)
PMID: 22832192

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Plasminogen Chains: A, B
Molecule details ›
Chains: A, B
Length: 791 amino acids
Theoretical weight: 88.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00747 (Residues: 20-810; Coverage: 100%)
Gene name: PLG
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL, SIA
Carbohydrate polymer
4 bound ligands:
Ligand CL 7 x CL
Ligand K 2 x K
Ligand BCT 2 x BCT
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P3221
Unit cell:
a: 144.62Å b: 144.62Å c: 233.67Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.19 0.216

Quick links

Citations

39 review citations

Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination.
Bhattacharya et al. (2012)
38 more

24 mentions without citation

Control of blood proteins by functional disulfide bonds.
Butera et al. (2014)
23 more