› 4duu

X-ray diffraction
5.2Å resolution

The X-ray Crystal Structure of Full-Length type I Human Plasminogen

Released:
DOI: 10.2210/pdb4duu/pdb
PDB entry 4duu coloured by chain, front view.
PDB entry 4duu coloured by chain, side view.
PDB entry 4duu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The X-ray crystal structure of full-length human plasminogen.
Law RH, Caradoc-Davies T, Cowieson N, Horvath AJ, Quek AJ, Encarnacao JA, Steer D, Cowan A, Zhang Q, Lu BG, Pike RN, Smith AI, Coughlin PB, Whisstock JC
Cell Rep 1 185-90 (2012)
PMID: 22832192

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen Chain: A
Molecule details ›
Chain: A
Length: 791 amino acids
Theoretical weight: 88.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00747 (Residues: 20-810; Coverage: 100%)
Gene name: PLG
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 110.12Å b: 110.12Å c: 234.815Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.27 0.268 0.312

Quick links

Citations

43 review citations

Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination.
Bhattacharya et al. (2012)
42 more

10 mentions without citation

Disorder and cysteines in proteins: A design for orchestration of conformational see-saw and modulatory functions.
Bhopatkar et al. (2020)
9 more