› 4dyl

X-ray diffraction
2.18Å resolution

F-BAR domain of human FES tyrosine kinase

Released:
DOI: 10.2210/pdb4dyl/pdb
PDB entry 4dyl coloured by chain, front view.
PDB entry 4dyl coloured by chain, side view.
PDB entry 4dyl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Salah E, Elkins J, Barr A, Krojer T, Filippakopoulos P, Weigelt J, Arrowsmith CH, Edwards A, Bountra C, von Delft F, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139510 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fes/Fps Chain: A
Molecule details ›
Chain: A
Length: 406 amino acids
Theoretical weight: 46.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07332 (Residues: 1-405; Coverage: 49%)
Gene names: FES, FPS
Sequence domains: Fes/CIP4, and EFC/F-BAR homology domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Unit cell:
a: 74.224Å b: 30.112Å c: 181.838Å
α: 90° β: 94.34° γ: 90°
R-values:
R R work R free
0.218 0.216 0.255
Expression system: Escherichia coli

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