› 4e0k

X-ray diffraction
0.97Å resolution

Crystal Structure of the amyloid-fibril forming peptide KDWSFY derived from human Beta 2 Microglobulin (58-63)

Released:
DOI: 10.2210/pdb4e0k/pdb
PDB entry 4e0k coloured by chain, front view.
PDB entry 4e0k coloured by chain, side view.
PDB entry 4e0k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.
Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D
Proc Natl Acad Sci U S A 109 20913-8 (2012)
PMID: 23213214

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158376 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin form pI 5.3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 6 amino acids
Theoretical weight: 846 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61769 (Residues: 78-83; Coverage: 6%)
Gene names: B2M, CDABP0092, HDCMA22P

Ligands and Environments

2 bound ligands:
Ligand PE4 2 x PE4
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P61
Unit cell:
a: 62.37Å b: 62.37Å c: 11.73Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.114 0.112 0.131
Expression system: Not provided

Quick links

Citations

26 review citations

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.
Jucker et al. (2013)
25 more

3 mentions without citation

Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.
Liu et al. (2012)
2 more