› 4e5a

X-ray diffraction
1.87Å resolution

The W197A mutant of p38a MAP kinase

Released:
DOI: 10.2210/pdb4e5a/pdb
PDB entry 4e5a coloured by chain, front view.
PDB entry 4e5a coloured by chain, side view.
PDB entry 4e5a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Lipid molecules induce p38α activation via a novel molecular switch.
Tzarum N, Eisenberg-Domovich Y, Gills JJ, Dennis PA, Livnah O
J Mol Biol 424 339-53 (2012)
PMID: 23079240

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: X
Molecule details ›
Chain: X
Length: 360 amino acids
Theoretical weight: 41.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 72.493Å b: 75.74Å c: 76.588Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.209 0.253
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases.
Yueh et al. (2019)
1 more

5 mentions without citation

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope.
Robinson et al. (2015)
4 more