› 4e83

X-ray diffraction
1.9Å resolution

Crystal structure of human alpha-defensin 5, HD5 (Leu29NLe mutant)

Released:
DOI: 10.2210/pdb4e83/pdb
PDB entry 4e83 coloured by chain, front view.
PDB entry 4e83 coloured by chain, side view.
PDB entry 4e83 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface.
Rajabi M, Ericksen B, Wu X, de Leeuw E, Zhao L, Pazgier M, Lu W
J Biol Chem 287 21615-27 (2012)
PMID: 22573326

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-169581 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HD5(63-94) Chains: A, B
Molecule details ›
Chains: A, B
Length: 32 amino acids
Theoretical weight: 3.59 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q01523 (Residues: 63-94; Coverage: 43%)
Gene names: DEF5, DEFA5
Sequence domains: Mammalian defensin

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
1 modified residue:
Ligand NLE 2 x NLE

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21212
Unit cell:
a: 39.229Å b: 60.772Å c: 20.392Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.243
Expression system: Not provided

Quick links

Citations

8 review citations

Paneth cells: maestros of the small intestinal crypts.
Clevers et al. (2013)
7 more

1 mention without citation

Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface.
Rajabi et al. (2012)