› 4ef5

X-ray diffraction
2.45Å resolution

Crystal structure of STING CTD

Released:
DOI: 10.2210/pdb4ef5/pdb
PDB entry 4ef5 coloured by chain, front view.
PDB entry 4ef5 coloured by chain, side view.
PDB entry 4ef5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding.
Ouyang S, Song X, Wang Y, Ru H, Shaw N, Jiang Y, Niu F, Zhu Y, Qiu W, Parvatiyar K, Li Y, Zhang R, Cheng G, Liu ZJ
Immunity 36 1073-86 (2012)
PMID: 22579474

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 29.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 139-379; Coverage: 64%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 81.041Å b: 90.356Å c: 73.315Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.226 0.288
Expression system: Escherichia coli

Quick links

Citations

76 review citations

Cyclic di-GMP: the first 25 years of a universal bacterial second messenger.
Römling et al. (2013)
75 more

12 mentions without citation

The Many Ways to Deal with STING.
Coderch et al. (2023)
11 more