› 4egx

X-ray diffraction
2.51Å resolution

Crystal structure of KIF1A CC1-FHA tandem

Released:
DOI: 10.2210/pdb4egx/pdb
PDB entry 4egx coloured by chain, front view.
PDB entry 4egx coloured by chain, side view.
PDB entry 4egx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The CC1-FHA tandem as a central hub for controlling the dimerization and activation of kinesin-3 KIF1A.
Huo L, Yue Y, Ren J, Yu J, Liu J, Yu Y, Ye F, Xu T, Zhang M, Feng W
Structure 20 1550-61 (2012)
PMID: 22863567

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171389 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF1A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 184 amino acids
Theoretical weight: 20.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12756 (Residues: 430-607; Coverage: 11%)
Gene names: ATSV, C2orf20, KIF1A
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand PEG 2 x PEG
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P212121
Unit cell:
a: 83.943Å b: 87.855Å c: 101.694Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.252 0.283
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance.
Prokop A. (2013)
5 more

2 mentions without citation

Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A.
Ren et al. (2016)
1 more