› 4eik

X-ray diffraction
1.6Å resolution

Crystal Structure of the Human Fyn SH3 domain in complex with the synthetic peptide VSL12

Released:
DOI: 10.2210/pdb4eik/pdb
PDB entry 4eik coloured by chain, front view.
PDB entry 4eik coloured by chain, side view.
PDB entry 4eik coloured by chain, top view.
Source organisms:
Primary publication:
Crystallization of and selenomethionine phasing strategy for a SETMAR-DNA complex.
Chen Q, Georgiadis M
Acta Crystallogr F Struct Biol Commun 72 713-9 (2016)
PMID: 27599863

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138966 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase Fyn Chain: A
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P06241 (Residues: 81-143; Coverage: 12%)
Gene name: FYN
Sequence domains: SH3 domain
Structure domains: SH3 Domains
VSL12 peptide Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.32 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P63
Unit cell:
a: 81.843Å b: 81.843Å c: 35.904Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.175 0.174 0.195
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

1 review citation

Structure, Activity, and Function of SETMAR Protein Lysine Methyltransferase.
Tellier M. (2021)
1 other article

8 mentions without citation

Benchmarking of different molecular docking methods for protein-peptide docking.
Agrawal et al. (2019)
7 more